(`AKRUTI Tech Plus’)
Offered by Bhabha Atomic Research Centre
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AKRUTI TECHNOLOGIES: De-Bittered Gourd (Karela ) juice with high Antidiabetic activity
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De-Bittered Bitter Gourd (Karela) juice with high antidiabetic activity

Bitter gourd (Momordica charantia L.), an annual climbing plant belonging to the Cucurbitaceae family, is an extensively investigated tropical medicinal plant. Its fruit, also known as balsam pear, bitter melon or karela has a distinct bitter taste which enhances as the fruit ripens. Bitter gourd has been popular as a natural remedy in Ayurvedic systems owing to its anti-diabetic, anti-malarial, anti-inflammatory, antiviral, contraceptive and insecticidal properties. Bitter gourd juice (BGJ) has a rich array of bioactive phytochemicals including vitamins, minerals and phenolic compounds. Phenolic compounds are known to possess both high antioxidant potential and anti-diabetic activity. Apart from phenolics several other bioactive molecules in bitter gourd include steroidal saponins, charantin, insulin like peptides, glycoalkaloids, vicine, momorcharin, oleanolic acids, triterpenes, trehalose and momordin. However, simple preparation of juice does not extract bioactive principals to the full extent. Moreover, although health benefits of bitter gourd are well documented and well known, its use is still limited due to its extremely bitter taste which limits its consumer acceptability. BARC has developed a technology for preparation of de-bitter Karela juice having high bioactivity.De-bitter Karela juice is prepared by using all GRAS chemicals and enzymes.


  • Simple and easy  method of  preparation
  • Clear appearance and is completely de-bittered
  • High antidiabetic activity
  • Better physiological properties (such as α-glucosidase and α-amylase inhibition as) compared to commercially available products


  • Can be used as an alternative for management of diabetes and obesity.


a. Raw Material required

  • Bitter gourd
  • Hydrolytic enzymes
  • Additives for de-bittering (GRAS status)

b. Equipments

  • Overhead stirrer with motor and temperature control
  • Fruit pulping machine
  • Bottle filling and pasteurizing machine

c. Space

  • Shade  or Covered room of 600 sq. ft. area (30 ft. x 20 ft) with potable water facilities.

d. Power

  • Both single and three phase power supply.

e. Manpower

  • Minimum two laboratory technician are required for production of 100 L of de-bittered juice. Actual manpower would depend on production capacity.

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